A recent study by the CDC has confirmed that both the Pfizer and Moderna COVID-19 vaccines are remarkably effective at preventing infections in everyday situations. The research indicates a significant 90% reduction in infection risk two weeks after receiving the second dose.
Conducted among healthcare workers and first responders from December 14, 2020, to March 13, 2021, the study highlighted that the vaccines effectively reduce both symptomatic and asymptomatic infections, providing reassurance beyond clinical trial data. One dose alone was shown to prevent 80% of infections, with the second dose enhancing that figure to 90%. This is particularly important as there has been ongoing debate about whether vaccinated individuals could still transmit the virus through asymptomatic infections, and the study suggests this is unlikely.
In addition to the standard concerns about the virus, the study was conducted during a period when several concerning variants were circulating, yet the vaccines maintained their effectiveness. Among the 3,950 participants, primarily high-risk individuals, 62.8% had completed the two-dose regimen, while 12.1% had received one dose. Each participant underwent weekly PCR testing, the most reliable method for detecting COVID-19, allowing researchers to identify both symptomatic and asymptomatic cases. Notably, 58% of infections were identified before any symptoms appeared, with only 10.2% of infected individuals remaining asymptomatic.
The most encouraging finding was that fully vaccinated participants experienced just 0.04 infections per 1,000 person-days, demonstrating excellent vaccine performance. Even among those who had received only one dose, the infection rate was still low at 0.19 per 1,000 person-days.
In summary, this study indicates that national vaccination efforts are proving effective, as emphasized by Dr. Mark Johnson, the CDC Director.
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Summary:
The CDC study confirms that Pfizer and Moderna vaccines significantly reduce COVID-19 infection rates, achieving a 90% effectiveness. This finding is particularly reassuring as it suggests low transmission risk among vaccinated individuals, despite circulating variants.

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