Why Vaccinated Individuals Experience ‘Breakthrough’ Infections

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Over the past few months, I’ve come to view the period from May to July as the “honeymoon phase” of COVID-19. Following a devastating winter surge, case numbers started to decline across the United States. Many essential workers and older individuals were fully vaccinated, and for those of us eager to get vaccinated, appointments were finally available. We began to reconnect with friends and family, sharing long-awaited embraces that brought tears of joy.

Social media was filled with photos of our reunions, often tagged with phrases like #thankyouscience and #vaccinesbringuscloser. These vaccines felt like miraculous breakthroughs, guiding us toward hope after such a dark time. With mRNA vaccines showing about 95% effectiveness, the CDC reassured us that vaccinated individuals, even if they did get infected, were unlikely to spread the virus to others.

For those of us fully vaccinated, it felt like we wore a protective shield. Even though our younger kids weren’t yet eligible for vaccination, we believed we could gather safely with other vaccinated individuals. But then, news about the Delta variant emerged—a highly transmissible strain that seemed to reduce the effectiveness of vaccines. Reports of fully vaccinated people contracting Delta began to surface. Although these cases were generally mild, they were still alarming for healthy, vaccinated individuals.

Confusion set in. How could this be happening? I felt anxious when I read a post by Alex Turner, who shared that his entire family caught COVID-19, despite three out of four being fully vaccinated. The virus began with his unvaccinated child and spread to the rest of the family. While his vaccinated teenager remained asymptomatic, he and his wife became ill.

Fortunately, like most vaccinated individuals who experience breakthrough infections, Alex and his wife dealt with relatively mild symptoms and recovered at home. Medical experts confirm that, despite Delta’s ability to evade vaccine protection, the vaccines continue to offer strong defense against severe illness and death—this is their primary purpose. Dr. Sarah Lee emphasized this point, stating, “The vaccine’s success lies in preventing illness.” The statistics are telling: over 97% of those hospitalized with COVID-19 were unvaccinated.

The CDC does not track mild breakthrough cases, making it challenging to fully grasp the current landscape of these infections. While media reports of breakthrough cases are increasing, it remains unclear how common they truly are among vaccinated individuals. Estimates of vaccine effectiveness against Delta have fluctuated, with figures ranging from 88% down to 39%.

In light of these developments, many are left wondering, “Why is this happening? Why aren’t the vaccines providing better protection against this virus?”

As science journalist Mia Roberts explains, breakthrough infections can occur for various reasons, and the Delta variant significantly increases the likelihood of these cases due to its heightened infectiousness. Delta is twice as transmissible as earlier COVID strains, and those infected can carry a viral load that is 1,000 times higher. Consequently, a vaccinated person exposed to Delta faces a greater challenge in combating the virus.

Mia notes, “A vaccinated individual exposed to a low viral dose may not get infected, but exposure to high levels of the Delta variant increases the risk of immune defenses being overwhelmed.” If infection occurs, however, a vaccinated person’s immune system is more adept at swiftly clearing the virus and typically results in milder symptoms.

Given these circumstances, many public health experts are advising even vaccinated individuals to resume precautions, such as wearing masks indoors. Vaccines are still remarkable tools, but with a highly transmissible virus in circulation, adopting a “layered” approach to safety makes sense, as public health expert Andy Slavitt suggests. Personally, I never stopped wearing a mask indoors, especially since I have a young child at home who is not yet eligible for vaccination. With the increased risk of breakthrough infections, I’m even more vigilant.

Moreover, as Dr. Emily Chang points out, a significant factor in the ongoing spread of COVID-19 is the number of unvaccinated individuals in our country. The combination of a highly contagious variant and unvaccinated populations leads to greater virus circulation, which raises the chances of vaccinated people becoming infected.

This situation highlights that combating this pandemic requires collective effort. It’s not only about individual protection—the effectiveness of vaccines improves with widespread vaccination. Delta is a stark reminder that we still have work to do.

So, for those who have yet to get vaccinated, please make the decision to do so, so that those of us who have taken the responsible step don’t have to bear the ongoing burden of this situation.

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In summary, the rise of breakthrough infections among vaccinated individuals can be attributed to the highly contagious nature of the Delta variant, which poses a greater challenge for the immune system. Public health experts advocate for continued precautions, emphasizing the importance of widespread vaccination to effectively combat the pandemic.


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